cafcit and Rasagiline Interactions

Interactions between cafcit(caffeine) and Rasagiline (rasagiline)

caffeine and rasagiline (Moderate Drug-Drug)

ADJUST DOSE: Coadministration with drugs that are inhibitors of CYP450 1A2 may increase the plasma concentrations of rasagiline, which is a substrate of the isoenzyme. In 12 healthy volunteers, coadministration with ciprofloxacin (500 mg twice a day) increased the systemic exposure (AUC) of rasagiline (2 mg once a day) by 83%, with no change in elimination half-life.

MANAGEMENT: Patients treated concomitantly with potent inhibitors of CYP450 1A2 such as ciprofloxacin or fluvoxamine should use rasagiline 0.5 mg/day. Patients receiving other CYP450 1A2 inhibitors should initiate therapy at the lower dosage, then increase gradually as necessary.