byetta and Lanoxin Interactions

Interactions between byetta(exenatide) and Lanoxin (digoxin)

digoxin and exenatide (Minor Drug-Drug)

Coadministration with exenatide may modestly affect the pharmacokinetic disposition of digoxin. The mechanism of interaction has not been described. Following repeated doses of exenatide (10 mcg twice a day), the peak plasma concentration (Cmax) of digoxin (0.25 mg orally once a day) was decreased by 17% and the time to reach peak plasma concentration (Tmax) was delayed by approximately 2.5 hours. However, the overall steady-state digoxin pharmacokinetic exposure (AUC) was unaltered.