Drug interactions between bupropion and Viramune
| Results for the following 2 drugs: |
|---|
| bupropion |
| Viramune (nevirapine) |
Interactions between your selected drugs
bupropion ↔ nevirapine
Applies to:bupropion and Viramune (nevirapine)
MONITOR: Coadministration with inducers of CYP450 2B6 may decrease the plasma concentrations of bupropion, which is primarily metabolized by the isoenzyme. In 13 study subjects, administration of a single 150 mg dose of sustained-release bupropion during treatment with the CYP450 2B6 inducer efavirenz (600 mg once daily for 14 days) decreased the bupropion peak plasma concentration (Cmax) by an average of 34% and systemic exposure (AUC) by an average of 55%. The Cmax of hydroxybupropion increased by 50%, with no change in AUC.
MANAGEMENT: Pharmacologic response to bupropion should be monitored more closely whenever a CYP450 2B6 inducer is added to or withdrawn from therapy, and the bupropion dosage adjusted as necessary. Increases in bupropion dosage should be guided by clinical response; however, the maximum recommended dosage of bupropion should not be exceeded.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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