Drug interactions between bupropion and Miradon
| Results for the following 2 drugs: |
|---|
| bupropion |
| Miradon (anisindione) |
Interactions between your selected drugs
bupropion ↔ anisindione
Applies to:bupropion and Miradon (anisindione)
MONITOR: Altered PT or INR, infrequently associated with hemorrhagic or thrombotic complications, has been observed during coadministration of bupropion and warfarin. The mechanism of interaction is unknown. In patients taking bupropion for smoking cessation, physiological changes resulting from smoking cessation itself may alter the pharmacokinetics of warfarin. Tobacco smoke is an inducer of hepatic microsomal enzymes, thus smoking cessation may increase blood concentrations of warfarin and other drugs that are extensively metabolized due to de-induction of the enzymes.
MANAGEMENT: Caution is advised if warfarin is given with bupropion. The INR should be checked regularly and warfarin dosage adjusted accordingly, particularly following initiation, discontinuation or change of dosage of bupropion in patients who are stabilized on their warfarin regimen. The same precaution may be applicable during therapy with other oral anticoagulants, although clinical data are lacking. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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