Drug interactions between buprenorphine and Tegretol XR
Results for the following 2 drugs: |
|
|---|---|
| buprenorphine | |
| Tegretol XR (carbamazepine) | |
Interactions between your selected drugs
carbamazepine ⇔ buprenorphine
Applies to: Tegretol XR (carbamazepine) and buprenorphine
MONITOR: Coadministration with drugs that are inducers of CYP450 3A4 may decrease the plasma concentrations and efficacy of buprenorphine, which is metabolized in the liver by the isoenzyme. In addition, some of these inducers (anticonvulsants and barbiturates) may have additive central nervous system-depressant effects with buprenorphine.
MANAGEMENT: Pharmacologic response to buprenorphine should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy, and the buprenorphine dosage adjusted as necessary. Ambulatory patients should be made aware of the possibility of additive effects (e.g., drowsiness, dizziness, lightheadedness, confusion) when taking other CNS-active drugs and counseled to avoid activities requiring mental alertness until they know how these agents affect them.
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