buprenorphine-hydrochloride and Alvimopan Interactions
Interactions between buprenorphine-hydrochloride(buprenorphine) and Alvimopan (alvimopan)
buprenorphine and alvimopan (Major Drug-Drug)
MANAGEMENT: The use of alvimopan is contraindicated in patients who have received therapeutic doses of opioids for more than 7 consecutive days immediately prior to alvimopan administration. Caution is advised in patients who have received more than 3 doses of an opioid within the week prior to surgery, as these patients were not studied in the postoperative ileus clinical trials. Patients with recent exposure to opioids should be monitored for increased adverse effects such as abdominal pain, nausea and vomiting, and diarrhea.
