Interactions between bumex(bumetanide) and Neomycin (neomycin)
bumetanide and neomycin (Major Drug-Drug)
GENERALLY AVOID: Coadministration of parenteral aminoglycoside antibiotics or oral neomycin in combination with loop diuretics may potentiate the risk of oto- and nephrotoxicity due to additive or synergistic pharmacologic effects of these drugs. The risk may be greater with high dosages of either drug, preexisting renal insufficiency, advanced age, dehydration, or the presence of other oto- or nephrotoxic drugs. The onset of ototoxicity may be greatly delayed, and cochlear damage may initially be asymptomatic. Reversible and irreversible hearing losses have been reported.
MANAGEMENT: The use of aminoglycoside antibiotics in combination with loop diuretics should generally be avoided. Serial, vestibular, audiometric, and renal function tests should be performed before and during therapy if coadministration is necessary.
