Drug interactions between Brilinta and Inderide
| Results for the following 2 drugs: |
|---|
| Brilinta (ticagrelor) |
| Inderide (hydrochlorothiazide/propranolol) |
Interactions between your selected drugs
propranolol ↔ ticagrelor
Applies to:Inderide (hydrochlorothiazide/propranolol) and Brilinta (ticagrelor)
Ventricular pauses and bradycardia, mostly asymptomatic, have been observed in clinical studies with ticagrelor. Theoretically, the risk of symptomatic bradycardia may be increased during concomitant use of other agents known to induce bradycardia. However, in PLATO, a large, randomized, double-blind efficacy and safety comparison study with clopidogrel in patients with acute coronary syndromes, no evidence of clinically significant adverse interactions was observed during concomitant administration with one or more drugs known to induce bradycardia including beta-blockers (96%), the calcium channel blockers diltiazem and verapamil (33%), and digoxin (4%).
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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