Drug interactions between bosentan and Lipitor
| Results for the following 2 drugs: |
|---|
| bosentan |
| Lipitor (atorvastatin) |
Interactions between your selected drugs
atorvastatin ↔ bosentan
Applies to:Lipitor (atorvastatin) and bosentan
MONITOR: Coadministration with bosentan may decrease the plasma concentrations of simvastatin and other HMG-CoA reductase inhibitors that are metabolized by the CYP450 3A4 isoenzyme. The mechanism is accelerated clearance due to induction of the isoenzyme by bosentan. According to the manufacturer, bosentan decreased the plasma concentrations of simvastatin and its active beta-hydroxy acid metabolite by approximately 50%.
MANAGEMENT: The possibility of diminished HMG-CoA reductase inhibitory activity should be considered during concomitant use of atorvastatin, cerivastatin, lovastatin, simvastatin, or red yeast rice (which contains lovastatin) with bosentan. Cholesterol levels should be checked following initiation or discontinuation of bosentan therapy, and the dosage of HMG-CoA reductase inhibitor adjusted accordingly. Pravastatin and fluvastatin may be reasonable alternatives, since they are metabolized by other hepatic enzymes.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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