Drug interactions between black cohosh and disulfiram
Results for the following 2 drugs: |
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|---|---|
| black cohosh | |
| disulfiram | |
Interactions between your selected drugs
disulfiram ⇔ black cohosh
Applies to: disulfiram and black cohosh
GENERALLY AVOID: Due to a potentially high alcohol content, tincture formulations of black cohosh may theoretically produce severe reactions when coadministered with disulfiram. The mechanism is inhibition of aldehyde dehydrogenase (ALDH) by disulfiram. Following ingestion of alcohol, inhibition of ALDH results in increased concentration of acetaldehyde, the accumulation of which produces an unpleasant physiologic response referred to as the "disulfiram reaction". Symptoms include flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, weakness, vertigo, blurred vision, and confusion. Severe reactions may result in respiratory depression, cardiovascular collapse, arrhythmias, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death.
MANAGEMENT: The use of black cohosh tinctures in combination with disulfiram should be avoided.
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