bismuth-subsalicylate and Adoxa tt Interactions

Interactions between bismuth-subsalicylate(bismuth subsalicylate) and Adoxa tt (doxycycline)

doxycycline and bismuth subsalicylate (Moderate Drug-Drug)

ADJUST DOSING INTERVAL: Administration of a bismuth-containing preparation within two to three hours of a tetracycline may significantly decrease serum tetracycline concentrations. Data are available for tetracycline and doxycycline. The proposed mechanism is chelation of tetracycline by bismuth.

MANAGEMENT: Administration of a tetracycline and bismuth-containing preparation should be separated by two to three hours. Patients should be monitored for diminished tetracycline efficacy.