biaxin-filmtab and Disopyramide extended release Interactions

Interactions between biaxin-filmtab(clarithromycin) and Disopyramide extended release (disopyramide)

clarithromycin and disopyramide (Major Drug-Drug)

GENERALLY AVOID: Some macrolide antibiotics may increase plasma levels of disopyramide. Life-threatening malignant arrhythmias and prolongation of the QT interval have been reported with erythromycin and clarithromycin.

MANAGEMENT: The concomitant use of these agents should be avoided with disopyramide. Monitoring of disopyramide levels may be useful if these drugs must be used together.