Drug interactions between Betimol and Norpace
| Results for the following 2 drugs: |
|---|
| Betimol (timolol ophthalmic) |
| Norpace (disopyramide) |
Interactions between your selected drugs
disopyramide ↔ timolol
Applies to:Norpace (disopyramide) and Betimol (timolol ophthalmic)
MONITOR: Due to its potent negative inotropic and chronotropic effects, disopyramide has been associated with severe hypotension, syncope, severe bradycardia, asystole, and heart failure when used with beta-blockers. Fatalities have been reported. Some beta-blockers have also been reported to decrease the clearance of disopyramide.
MONITOR: The use of disopyramide has been associated with rare cases of significant hypoglycemia. Since beta-blockers may inhibit some of the normal physiologic response to hypoglycemia, glucoregulatory mechanisms (in the absence of food) may be compromised. Specifically, inhibition of catecholamine-mediated glycogenolysis and glucose mobilization in association with beta-blockade can potentiate the hypoglycemia and delay recovery of normal blood glucose levels. In addition, symptoms of hypoglycemia such as tremors and tachycardia may be absent, making it more difficult for patients to recognize an oncoming episode. These effects may be more likely with noncardioselective beta-blockers (e.g., propranolol, pindolol, timolol) but may occasionally also occur with relatively beta-1 selective agents (e.g., atenolol, metoprolol), particularly at higher dosages.
MANAGEMENT: Although the interaction with disopyramide has not been reported when beta-blockers are administered ophthalmically, caution is advised because they are systemically absorbed and can produce clinically significant systemic effects even at low or undetectable plasma levels. Patients should be advised to seek medical attention if they experience dizziness, lightheadedness, syncope, palpitations, slow or fast pulse, or irregular heartbeats.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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