benemid and Toradol Interactions

Interactions between benemid(probenecid) and Toradol (ketorolac)

probenecid and ketorolac (Major Drug-Drug)

CONTRAINDICATED: The concomitant administration of probenecid and ketorolac may cause ketorolac toxicity. Probenecid decreases the plasma clearance of ketorolac, resulting in a three-fold increase in ketorolac AUC and a two-fold increase in its half-life. Renal failure, GI ulcerations or perforation, and hemorrhage may occur.

MANAGEMENT: The manufacturer considers the concurrent use of probenecid and ketorolac contraindicated.