Interactions between benemid(probenecid) and Toradol iv im (ketorolac)
probenecid and ketorolac (Major Drug-Drug)
CONTRAINDICATED: The concomitant administration of probenecid and ketorolac may cause ketorolac toxicity. Probenecid decreases the plasma clearance of ketorolac, resulting in a three-fold increase in ketorolac AUC and a two-fold increase in its half-life. Renal failure, GI ulcerations or perforation, and hemorrhage may occur.
MANAGEMENT: The manufacturer considers the concurrent use of probenecid and ketorolac contraindicated.
