Interactions between benemid(probenecid) and Sodium phenylacetate (sodium phenylacetate)
probenecid and sodium phenylacetate (Moderate Drug-Drug)
GENERALLY AVOID: Probenecid is known to inhibit the renal transport of many organic compounds, including aminohippuric acid, and may affect the renal excretion of phenylacetylglutamine and hippurate, the byproducts formed when sodium phenylacetate and sodium benzoate are administered for the treatment of acute hyperammonemia in patients with urea cycle disorders. Since phenylacetylglutamine and hippurate serve as vehicles to reduce waste nitrogen levels in such patients, adequate renal excretion is necessary to treat hyperammonemia and reduce the risk of glutamine-induced neurotoxicity.
MANAGEMENT: Although the interaction is theoretical and no data are available, it may be appropriate to avoid using probenecid during treatment of acute hyperammonemia in patients with urea cycle disorders due to the urgent nature of the condition. Uncontrolled hyperammonemia can rapidly result in brain damage or death.
