benemid and Rheumatrex dose pack Interactions

Interactions between benemid(probenecid) and Rheumatrex dose pack (methotrexate)

probenecid and methotrexate (Major Drug-Drug)

MONITOR CLOSELY: Probenecid inhibits the renal elimination of methotrexate. The pharmacologic effect and toxicity of methotrexate may be increased, especially in patients receiving high-dose methotrexate.

MANAGEMENT: If this combination must be used, a reduction in methotrexate dosage may be needed and the patient should be closely monitored for signs and symptoms of bone marrow suppression, hepatotoxicity, and nephrotoxicity. Patients should be advised to promptly report symptoms including fever, chills, sore throat, bruising, bleeding, stomatitis, malaise, shortness of breath, lower extremity edema, jaundice, or change in stool or urine color to their physician.