benemid and Mycophenolic acid Interactions

Interactions between benemid(probenecid) and Mycophenolic acid (mycophenolic acid)

probenecid and mycophenolic acid (Moderate Drug-Drug)

MONITOR: Animal studies have shown that coadministration with probenecid results in a 2-fold increase in the systemic exposure (AUC) of mycophenolic acid and a 3-fold increase in the AUC of mycophenolic acid glucuronide, an inactive metabolite. The proposed mechanism is competition of these agents for renal tubular secretion.

MANAGEMENT: Caution is advised if mycophenolic acid products must be used concomitantly with probenecid. The dosage of one or both drugs may require adjustments.