Interactions between benemid(probenecid) and Doripenem (doripenem)
probenecid and doripenem (Moderate Drug-Drug)
GENERALLY AVOID: Coadministration with probenecid may increase the plasma concentrations of doripenem. The mechanism involves competitive inhibition of the renal excretion of doripenem via active tubular secretion. In pharmacokinetic studies, probenecid increased doripenem systemic exposure (AUC) by 75% and plasma elimination half-life by 53%.
MANAGEMENT: The use of doripenem in combination with probenecid is not recommended by the manufacturer.
