benemid and Depen Interactions

Interactions between benemid(probenecid) and Depen (penicillamine)

probenecid and penicillamine (Moderate Drug-Drug)

GENERALLY AVOID: Probenecid may interfere with penicillamine metabolite elimination. The therapeutic effect of penicillamine may be reduced and increased toxicity may occur. In one study with two cystinuric patients given single doses of probenecid and penicillamine, increased cysteine excretion and decreased excretion of penicillamine metabolites occurred. There are no other reports of this interaction in the literature.

MANAGEMENT: Concomitant use should be avoided in cystinuric patients.