benemid and Ddc Interactions

Interactions between benemid(probenecid) and Ddc (zalcitabine)

probenecid and zalcitabine (Moderate Drug-Drug)

MONITOR: Probenecid may increase plasma concentrations and decrease clearance of zalcitabine. The mechanism may be inhibition of renal tubular secretion of zalcitabine.

MANAGEMENT: Close clinical monitoring for evidence of zalcitabine toxicity (peripheral neuropathy, pancreatitis, lactic acidosis, hepatotoxicity) is recommended when these drugs are used together. In addition, a reduction in zalcitabine dosage may be warranted. Patients should be advised to promptly notify their physician if they experience numbness, tingling, severe nausea and vomiting, diarrhea, abdominal pain, severe fatigue, jaundice, or unusual bleeding or bruising.