benemid and Dapsone Interactions

Interactions between benemid(probenecid) and Dapsone (dapsone)

probenecid and dapsone (Moderate Drug-Drug)

MONITOR: Probenecid may inhibit the renal tubular secretion of dapsone. Serum dapsone levels and the risk of toxicity may be increased.

MANAGEMENT: Patients should be monitored for signs of dapsone toxicity, such as nausea, vomiting, hyperexcitability, seizures, muscle weakness, peripheral neuropathy, methemoglobinemia, or blood dyscrasias.