benemid and Azt Interactions

Interactions between benemid(probenecid) and Azt (zidovudine)

probenecid and zidovudine (Moderate Drug-Drug)

MONITOR: Probenecid inhibits the renal excretion and glucuronidation of zidovudine, and serum zidovudine levels may be increased. The patient may be exposed to a greater risk of zidovudine toxicity.

MANAGEMENT: Patients should be monitored for signs of zidovudine toxicity (anemia, nausea, headache, myalgia, malaise, fever, or rash). Zidovudine dosage may need to be reduced, or the dosing interval may need to be lengthened.