Drug interactions between Bactrim and cyclosporine
| Results for the following 2 drugs: |
|---|
| Bactrim (sulfamethoxazole/trimethoprim) |
| cyclosporine |
Interactions between your selected drugs
cyclosporine ↔ sulfamethoxazole
Applies to:cyclosporine and Bactrim (sulfamethoxazole/trimethoprim)
MONITOR CLOSELY: Sulfonamides may significantly reduce serum cyclosporine concentrations by an unknown mechanism. Allograft rejections have resulted. Hyperkalemia and additive nephrotoxicity has also been reported. The mechanism is unknown. Data are available for intravenous trimethoprim-sulfamethoxazole, intravenous sulfamethazine (no longer marketed), oral sulfadiazine, and sulfasalazine. Oral trimethoprim-sulfamethoxazole reportedly does not affect cyclosporine levels.
MANAGEMENT: Renal function and cyclosporine levels should be closely monitored if these drugs must be used concomitantly.
cyclosporine ↔ trimethoprim
Applies to:cyclosporine and Bactrim (sulfamethoxazole/trimethoprim)
MONITOR: Increased serum creatinine levels and decreased efficacy of cyclosporine have been reported when administered concurrently with trimethoprim. The mechanism of this interaction is unknown.
MANAGEMENT: Caution is advised if these medications must be used concomitantly. The patient's renal function and efficacy and safety of both drugs should be monitored during concomitant administration. Use of an alternative antibiotic may be appropriate.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. Multum's drug information does not endorse drugs, diagnose patients, or recommend therapy. Multum's drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2012 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
