bacitracin and Doxacurium Interactions

Interactions between bacitracin and Doxacurium (doxacurium)

doxacurium and bacitracin (Moderate Drug-Drug)

MONITOR: Like other polypeptide antibiotics, systemically administered bacitracin may prolong apnea and respiratory paralysis associated with the use of nondepolarizing neuromuscular blocking agents. The mechanism may involve decreased intracellular potassium or decreased ionized serum calcium, as intravenous calcium administration has been reported to be helpful in reversing paralysis caused by polymyxin B in some cases.

MANAGEMENT: Patients should be closely monitored for prolonged or excessive neuromuscular blockade.