Drug interactions between azithromycin and Lipitor
Results for the following 2 drugs: |
|
|---|---|
| azithromycin | |
| Lipitor (atorvastatin) | |
Interactions between your selected drugs
azithromycin ⇔ atorvastatin
Applies to: azithromycin and Lipitor (atorvastatin)
MONITOR: Azithromycin has been implicated in a single case of rhabdomyolysis during lovastatin treatment. The mechanism of interaction is unknown. Macrolide antibiotics that inhibit CYP450 3A4 may significantly increase the plasma concentrations of HMG-CoA reductase inhibitors; however, azithromycin is generally believed to have little, if any, effect on this isoenzyme. In 12 healthy patients treated with atorvastatin (10 mg once a day for 8 days), the pharmacokinetics of atorvastatin were not significantly changed following 3 days of azithromycin (500 mg once a day from days 6 through 8).
MANAGEMENT: Until further data are available, caution is advised if azithromycin is prescribed to patients treated with HMG-CoA reductase inhibitors or red yeast rice (which contains lovastatin). Patients should be advised to promptly report any unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever. The HMG-CoA reductase inhibitor should be discontinued if creatine kinase is markedly elevated or if myopathy is suspected or diagnosed.
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