Drug interactions between Azilect and Ultram
| Results for the following 2 drugs: |
|---|
| Azilect (rasagiline) |
| Ultram (tramadol) |
Interactions between your selected drugs
tramadol ↔ rasagiline
Applies to:Ultram (tramadol) and Azilect (rasagiline)
CONTRAINDICATED: Monoamine oxidase inhibitors (MAOIs) may potentiate the serotonergic activity of tramadol and increase the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5HT1A receptors. The mechanism is an additive pharmacodynamic effect resulting from MAOI inhibition of serotonin metabolism. Patients receiving this combination of drugs may also experience an increased risk of seizures due to lowering of seizure threshold.
MANAGEMENT: Concurrent use of tramadol and MAOIs or other agents that possess MAOI activity (e.g., furazolidone, procarbazine) is considered contraindicated. At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with tramadol.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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