avapro and Abilify Interactions

Interactions between avapro(irbesartan) and Abilify (aripiprazole)

irbesartan and aripiprazole (Moderate Drug-Drug)

MONITOR: Neuroleptic agents may potentiate the hypotensive effect of some medications secondary to their peripheral alpha-1 adrenergic blocking activity. Orthostatic hypotension and syncope associated with vasodilation may occur, particularly during the initial dose titration period of neuroleptic therapy.

MANAGEMENT: Close clinical monitoring for development of hypotension is recommended if neuroleptic agents are prescribed with antihypertensive medications or vasodilators. Patients should be advised to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia. A lower starting dosage and slower titration of the neuroleptic agent may be appropriate in patients receiving antihypertensive therapy, especially if they are elderly.