Drug interactions between Avandaryl and Singulair
| Results for the following 2 drugs: |
|---|
| Avandaryl (glimepiride/rosiglitazone) |
| Singulair (montelukast) |
Interactions between your selected drugs
montelukast ↔ rosiglitazone
Applies to:Singulair (montelukast) and Avandaryl (glimepiride/rosiglitazone)
MONITOR: Coadministration with inhibitors of CYP450 2C8 may increase the plasma concentrations of rosiglitazone, which is primarily metabolized by the isoenzyme. In a pharmacokinetic study, coadministration of rosiglitazone (4 mg once daily) and the potent CYP450 2C8 inhibitor gemfibrozil (600 mg twice daily) for 7 days resulted in a 127% increase in rosiglitazone systemic exposure (AUC) compared to administration of rosiglitazone alone. In a study of 10 healthy volunteers, pretreatment with another CYP450 2C8 inhibitor, trimethoprim (160 mg orally twice a day for 4 days), increased the mean peak plasma concentration (Cmax) and AUC of rosiglitazone (4 mg single oral dose) by 14% and 37%, respectively, compared to placebo. The half-life of rosiglitazone was prolonged from 3.8 to 4.8 hours. Nearly identical results were reported in eight healthy volunteers in another study administered trimethoprim and rosiglitazone.
MANAGEMENT: Given the potential for dose-related adverse events with rosiglitazone, caution is advised during coadministration with CYP450 2C8 inhibitors. Close monitoring for the development of hypoglycemia and other adverse effects of rosiglitazone such as fluid retention, heart failure, and pulmonary and peripheral edema is recommended. Patients should be advised to regularly monitor their blood sugar and counseled on how to recognize and treat hypoglycemia, which may include symptoms such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, and palpitations. The physician should be notified if an interaction is suspected.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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