Drug interactions between aspirin/butalbital/caffeine/codeine and Synthroid
| Results for the following 2 drugs: |
|---|
| aspirin/butalbital/caffeine/codeine |
| Synthroid (levothyroxine) |
Interactions between your selected drugs
levothyroxine ↔ butalbital
Applies to:Synthroid (levothyroxine) and aspirin/butalbital/caffeine/codeine
MONITOR: Barbiturates may decrease exogenous thyroid plasma concentrations resulting in elevated thyroid stimulating hormone (TSH) and exacerbation of hypothyroidism. The mechanism may be induction of hepatic CYP450 enzymes responsible for thyroxine (T4) and triiodothyronine (T3) metabolism. Clinical data are limited.
MANAGEMENT: Clinical monitoring of patient response, including laboratory serum TSH concentrations, is recommended. Adjustment of thyroid replacement dosage may be indicated when initiating or discontinuing barbiturate therapy.
See also...
- Aspirin/butalbital/caffeine/codeine Drug Interactions
- aspirin, butalbital, caffeine, and codeine General Consumer Information
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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