Drug interactions between Aspirin Buffered and ticlopidine
| Results for the following 2 drugs: |
|---|
| Aspirin Buffered (aluminum hydroxide/aspirin/calcium carbonate/magnesium hydroxide) |
| ticlopidine |
Interactions between your selected drugs
aspirin ↔ ticlopidine
Applies to:Aspirin Buffered (aluminum hydroxide/aspirin/calcium carbonate/magnesium hydroxide) and ticlopidine
MONITOR: Although their use often overlaps in clinical practice, ticlopidine has been reported to potentiate the effect of aspirin on collagen-induced platelet aggregation. Other salicylates may also be affected. The risk of bleeding may be increased, especially in patients with a history of gastrointestinal (GI) ulceration or bleeding. The manufacturer of ticlopidine recommends against concomitant long-term use of aspirin. In many patients who have received implanted cardiac stents, however, ticlopidine and aspirin are used concomitantly for anticoagulant effects.
MANAGEMENT: Patients should be monitored for signs and symptoms of bleeding, especially GI bleeding, if aspirin or salicylates and ticlopidine are coadministered. Patients should be advised to promptly report any signs of bleeding to their physician, including abdominal pain, vomiting blood, red or black stools, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, nosebleeds, bleeding of gums from brushing, red or brown urine, or other unusual bleeding or bruising. Patients should also be counseled to avoid any other over-the-counter salicylate products.
calcium carbonate ↔ ticlopidine
Applies to:Aspirin Buffered (aluminum hydroxide/aspirin/calcium carbonate/magnesium hydroxide) and ticlopidine
Coadministration of oral medications that contain magnesium, aluminum, calcium, or sodium (i.e., antacids) has decreased ticlopidine serum concentrations by 18%. Administration of these drugs should be separated by at least three hours.
ticlopidine ↔ aluminum hydroxide
Applies to:ticlopidine and Aspirin Buffered (aluminum hydroxide/aspirin/calcium carbonate/magnesium hydroxide)
Coadministration of oral medications that contain magnesium, aluminum, calcium, or sodium (i.e., antacids) has decreased ticlopidine serum concentrations by 18%. Administration of these drugs should be separated by at least three hours.
ticlopidine ↔ magnesium hydroxide
Applies to:ticlopidine and Aspirin Buffered (aluminum hydroxide/aspirin/calcium carbonate/magnesium hydroxide)
Coadministration of oral medications that contain magnesium, aluminum, calcium, or sodium (i.e., antacids) has decreased ticlopidine serum concentrations by 18%. Administration of these drugs should be separated by at least three hours.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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