Drug interactions between Aspirin Buffered and Cardizem SR
Results for the following 2 drugs: |
|
|---|---|
| Aspirin Buffered (aluminum hydroxide/aspirin/calcium carbonate/magnesium hydroxide) | |
| Cardizem SR (diltiazem) | |
Interactions between your selected drugs
diltiazem ⇔ calcium carbonate
Applies to: Cardizem SR (diltiazem) and Aspirin Buffered (aluminum hydroxide/aspirin/calcium carbonate/magnesium hydroxide)
MONITOR: Calcium-containing products may decrease the effectiveness of calcium channel blockers by saturating calcium channels with calcium. Calcium chloride has been used to manage acute severe verapamil toxicity.
MANAGEMENT: Management consists of monitoring the effectiveness of calcium channel blocker therapy during coadministration with calcium products.
diltiazem ⇔ aspirin
Applies to: Cardizem SR (diltiazem) and Aspirin Buffered (aluminum hydroxide/aspirin/calcium carbonate/magnesium hydroxide)
MONITOR: Several case reports have suggested that verapamil and aspirin may have synergistic antiplatelet effects. The mechanism of this interaction has not been fully elucidated. Also, one study of five patients has suggested that aspirin may reverse the antihypertensive effect of verapamil. The mechanism may be related to antagonism of the effect of verapamil on prostacyclin. Diltiazem has been shown to interact with aspirin in a similar manner.
MANAGEMENT: Close observation for prolonged bleeding time and reduced antihypertensive effect is recommended if these drugs must be used together. Patients should be advised to notify their physician if they experience unusual bleeding, bruising, or petechiae. Aspirin should be discontinued if an interaction is suspected.
See also...
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