Drug interactions between Asendin and Eskalith
Results for the following 2 drugs: |
|
|---|---|
| Asendin (amoxapine) | |
| Eskalith (lithium) | |
Interactions between your selected drugs
lithium ⇔ amoxapine
Applies to: Eskalith (lithium) and Asendin (amoxapine)
MONITOR: The concomitant use of lithium and tricyclic antidepressants (TCAs) may potentiate the risk of neurotoxicity and psychotic symptoms, even at therapeutic serum lithium levels. The mechanism is unknown but may be related to synergistic effects on neurotransmission. Mania, myoclonus, tremors, memory difficulties, confusion, serotonin syndrome, and a neuroleptic malignant-like syndrome have been reported in patients treated with TCAs several days after the addition of lithium, in most cases requiring discontinuation of either the TCA or lithium. Elderly patients may be particularly susceptible to this interaction.
MANAGEMENT: Close monitoring for symptoms of neurotoxicity is recommended if TCAs are used with lithium. Dosage adjustment or discontinuation of one or both drugs may be necessary if an interaction is suspected.
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