Drug interactions between aripiprazole and Prozac
Results for the following 2 drugs: |
|
|---|---|
| aripiprazole | |
| Prozac (fluoxetine) | |
Interactions between your selected drugs
fluoxetine ⇔ aripiprazole
Applies to: Prozac (fluoxetine) and aripiprazole
ADJUST DOSE: Coadministration with quinidine or other potent inhibitors of CYP450 2D6 may significantly increase the plasma concentrations of aripiprazole, which is partially metabolized by the isoenzyme. According to the manufacturer, quinidine (166 mg/day for 13 days) increased the area under the plasma concentration-time curve (AUC) of aripiprazole (10 mg single dose) by 112%. The AUC of its active metabolite, dehydro-aripiprazole, was decreased by 35%.
MANAGEMENT: Pharmacologic response to aripiprazole should be monitored more closely whenever quinidine or other potent inhibitors of CYP450 2D6 (e.g., fluoxetine, paroxetine, cinacalcet) are added to or withdrawn from therapy. The manufacturer recommends that aripiprazole dosage be reduced to one-half the normal dosage during concomitant administration with quinidine, and additional dosage adjustments be based on clinical evaluation. Similar dosage adjustments should be made during coadministration with other potent CYP450 2D6 inhibitors. Aripiprazole dosage should be increased accordingly if these agents are discontinued.
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