Drug interactions between Aricept and propoxyphene
Results for the following 2 drugs: |
|
|---|---|
| Aricept (donepezil) | |
| propoxyphene | |
Interactions between your selected drugs
propoxyphene ⇔ donepezil
Applies to: propoxyphene and Aricept (donepezil)
Coadministration with inhibitors of CYP450 2D6 and/or 3A4 may increase the plasma concentrations of donepezil, which is primarily metabolized by these isoenzymes. In a 7-day crossover study in 18 healthy volunteers, the potent CYP450 3A4 inhibitor ketoconazole (200 mg once daily) increased the mean peak plasma concentration (Cmax) and systemic exposure (AUC) of donepezil (5 mg once daily) by approximately 36% each. The clinical relevance of these increases is unknown.
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