Drug interactions between Aricept and primidone
Results for the following 2 drugs: |
|
|---|---|
| Aricept (donepezil) | |
| primidone | |
Interactions between your selected drugs
primidone ⇔ donepezil
Applies to: primidone and Aricept (donepezil)
MONITOR: Coadministration with drugs that are inducers of the CYP450 3A4 and/or 2D6 enzymatic pathways may decrease the plasma concentrations of donepezil. The mechanism is accelerated clearance of donepezil due to enhanced CYP450 activities.
MANAGEMENT: While clinical data are lacking, the possibility of a diminished therapeutic response to donepezil should be considered in patients receiving concomitant inducer agents.
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