Drug interactions between argatroban and Miradon
| Results for the following 2 drugs: |
|---|
| argatroban |
| Miradon (anisindione) |
Interactions between your selected drugs
anisindione ↔ argatroban
Applies to:Miradon (anisindione) and argatroban
MONITOR: Although their use often overlaps in clinical practice, the concomitant use of thrombin inhibitors and other anticoagulants may increase the risk of bleeding complications due to additive or synergistic effects on the clotting cascade. A small clinical trial (n=12) reported two minor bleeding events, but no pharmacokinetic interaction or serious adverse events after administration of low-dose argatroban and single-dose warfarin.
MANAGEMENT: Coadministration of thrombin inhibitors and all anticoagulants should be undertaken with caution and only after thorough assessment of risks and benefits. Current guidelines for transitioning from thrombin inhibitors to warfarin may be consulted. Close clinical and laboratory observation for bleeding complications is recommended.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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