Drug interactions between Aredia and Thalomid
| Results for the following 2 drugs: |
|---|
| Aredia (pamidronate) |
| Thalomid (thalidomide) |
Interactions between your selected drugs
pamidronate ↔ thalidomide
Applies to:Aredia (pamidronate) and Thalomid (thalidomide)
MONITOR: In multiple myeloma patients, the risk of renal dysfunction may be increased when intravenous bisphosphonates are used in combination with thalidomide. The mechanism of interaction has not been described.
MANAGEMENT: Caution is advised if pamidronate, zoledronic acid, or other intravenous formulations of bisphosphonates must be used in multiple myeloma patients who are receiving treatment with thalidomide. Renal function and serum electrolytes should be monitored. Product labelings for pamidronate and zoledronic acid recommend that single doses not exceed 90 mg and 4 mg, respectively, and the duration of infusion not less than 2 hours and 15 minutes, respectively. Patients should have serum creatinine assessed prior to each treatment, and treatment should be withheld for renal deterioration. In those treated for bone metastases, treatment should not be resumed until renal function returns to baseline.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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