Drug interactions between Aquachloral Supprettes and Miradon
| Results for the following 2 drugs: |
|---|
| Aquachloral Supprettes (chloral hydrate) |
| Miradon (anisindione) |
Interactions between your selected drugs
chloral hydrate ↔ anisindione
Applies to:Aquachloral Supprettes (chloral hydrate) and Miradon (anisindione)
MONITOR: Chloral hydrate may temporarily potentiate the hypoprothrombinemic effect of warfarin and similar anticoagulants. The mechanism is protein binding displacement by trichloroacetic acid, a major metabolite of chloral hydrate, resulting in increased plasma concentrations of unbound (active) anticoagulant drug. However, since drug clearance is also increased with higher levels of unbound drug, the pharmacokinetic effects produced by chloral hydrate tend to balance out over time, resulting in little or no net effect on anticoagulation therapy in the long-term. The manufacturer of triclofos cautions that it may also interact with anticoagulants.
MANAGEMENT: Based on these observations, appropriate monitoring for excessive hypoprothrombinemia (INR/PT) is recommended for several days following the addition of chloral hydrate or triclofos to a stabilized regimen of warfarin or other oral anticoagulants. Consideration may be given to using other sedative/hypnotic agents that have not been shown to interact with oral anticoagulants such as benzodiazepines or diphenhydramine. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
See also...
- Aquachloral Supprettes Drug Interactions
- Aquachloral Supprettes Suppositories General Consumer Information
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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