Interactions between anzemet(dolasetron) and Bumex (bumetanide)
bumetanide and dolasetron (Major Drug-Drug)
MONITOR CLOSELY: The risk of arrhythmia may be increased in patients taking dolasetron and diuretics. Dolasetron induced ECG changes (PR and QTc prolongation; QRS widening) have been observed in healthy volunteers and in controlled clinical trials. Diuretics may further predispose the patient to arrhythmia by inducing electrolyte abnormalities.
MANAGEMENT: Close clinical and laboratory monitoring for cardiac rhythm and electrolyte disturbances is recommended if this combination is used.
