Drug interactions between Anzemet and tramadol
| Results for the following 2 drugs: |
|---|
| Anzemet (dolasetron) |
| tramadol |
Interactions between your selected drugs
tramadol ↔ dolasetron
Applies to:tramadol and Anzemet (dolasetron)
MONITOR: Concurrent use of 5-HT3 receptor antagonists may reduce the analgesic efficacy of tramadol. The proposed mechanism is antagonism of serotonin-mediated effects of tramadol at the spinal level. In a randomized, double-blind study of 40 patients undergoing lumbar laminectomy, patients who were administered ondansetron 4 mg at induction of anesthesia required more tramadol postsurgery than control patients who had been given saline. Cumulative tramadol use via a PCA pump was 26% to 35% higher in the ondansetron group the first 4 hours postoperatively and 22% to 25% higher thereafter. Tramadol use on an hourly basis did not differ significantly between the two groups except in the first postoperative hour, probably because of the relatively short plasma half-life of ondansetron. The 4 mg dose of ondansetron did not reduce the 24-hour incidence of postoperative nausea and vomiting.
MANAGEMENT: No particular intervention is required. However, the possibility of a diminished therapeutic response to tramadol should be considered during concomitant therapy with 5-HT3 receptor antagonists.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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