anturane and Actos Interactions

Interactions between anturane(sulfinpyrazone) and Actos (pioglitazone)

sulfinpyrazone and pioglitazone (Moderate Drug-Drug)

MONITOR: Pioglitazone is metabolized by CYP450 3A4 microsomal enzymes in the liver. The clinician should be aware of the potential for an interaction when pioglitazone is used in combination with another medication that induces CYP450 3A4.

MANAGEMENT: The patient should be observed for clinical and laboratory evidence of altered safety and efficacy of both drugs if pioglitazone is added to or removed from the patients medication regimen. Patients should be advised to report loss of blood sugar control to their physician.