anturane and Actamin Interactions

Interactions between anturane(sulfinpyrazone) and Actamin (acetaminophen)

acetaminophen and sulfinpyrazone (Moderate Drug-Drug)

MONITOR: Sulfinpyrazone may increase the potential hepatotoxicity of acetaminophen and decrease its pharmacologic effects. The mechanism may be related to accelerated metabolism of acetaminophen with consequent increased hepatotoxic metabolites. This interaction is of greatest concern in cases of acetaminophen overdose. Data have been limited.

MANAGEMENT: Until more information is available, the use of this combination over a prolonged period of time should probably be avoided. Special dosage adjustments are not needed with normal therapeutic dosages of both agents. Monitoring for clinical and laboratory evidence of hepatotoxicity is recommended.