anturane and Acetohexamide Interactions

Interactions between anturane(sulfinpyrazone) and Acetohexamide (acetoHEXAMIDE)

acetoHEXAMIDE and sulfinpyrazone (Moderate Drug-Drug)

MONITOR: The concomitant administration of pyrazolones may increase the hypoglycemic effects of sulfonylureas. Data have been variable. The proposed mechanisms include pyrazolone inhibition of sulfonylurea metabolism, inhibition of renal clearance and/or displacement from protein binding sites.

MANAGEMENT: Patients receiving this combination should be monitored for increased hypoglycemic effects and advised to regularly monitor their blood sugar, counseled on how to recognize and treat hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, tremor, hunger, weakness, or palpitations) and to notify their physician if it occurs. The sulfonylurea dosage may require reduction in affected patients.