antizol and Ethyl alcohol Interactions

Interactions between antizol(fomepizole) and Ethyl alcohol (ethanol)

ethanol and fomepizole (Major Drug-Drug)

GENERALLY AVOID: The manufacturer reports that oral doses of fomepizole (10 to 20 mg/kg) will significantly reduce the rate of elimination of moderate doses of ethanol by approximately 40% when given to healthy volunteers. The mechanism of action is via alcohol dehydrogenase inhibition. By a similar mechanism, ethanol will decrease the rate of elimination of fomepizole.

MANAGEMENT: In general, ethanol and fomepizole should not be coadministered in the treatment of ethylene glycol poisoning.