Drug interactions between Anestacaine and ibutilide
| Results for the following 2 drugs: |
|---|
| Anestacaine (lidocaine) |
| ibutilide |
Interactions between your selected drugs
lidocaine ↔ ibutilide
Applies to:Anestacaine (lidocaine) and ibutilide
MONITOR: Amide-type local anesthetics may have additive cardiac effects (e.g., bradycardia, chest pain, heart block, arrhythmias, ECG abnormalities, cardiac arrest) with class III antiarrhythmic agents. Although specific trials studying the interaction have not been performed, a case report suggests additive depressive effects of amiodarone and lidocaine on the sinoatrial node. A 64-year-old man with sick sinus syndrome developed severe, symptomatic sinus bradycardia and sinoatrial arrest following local anesthesia with lidocaine while he was on amiodarone therapy. No other cause was identified.
MANAGEMENT: Patients treated with class III antiarrhythmic agents (e.g., amiodarone, dofetilide, ibutilide, sotalol) should be under close surveillance during administration of amide-type local anesthetics. ECG monitoring should be considered.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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