Drug interactions between Amytal Sodium and Synthroid
Results for the following 2 drugs: |
|
|---|---|
| Amytal Sodium (amobarbital) | |
| Synthroid (levothyroxine) | |
Interactions between your selected drugs
amobarbital ⇔ levothyroxine
Applies to: Amytal Sodium (amobarbital) and Synthroid (levothyroxine)
MONITOR: Barbiturates may decrease exogenous thyroid plasma concentrations resulting in elevated thyroid stimulating hormone (TSH) and exacerbation of hypothyroidism. The mechanism may be induction of hepatic CYP450 enzymes responsible for thyroxine (T4) and triiodothyronine (T3) metabolism. Clinical data are limited.
MANAGEMENT: Clinical monitoring of patient response, including laboratory serum TSH concentrations, is recommended. Adjustment of thyroid replacement dosage may be indicated when initiating or discontinuing barbiturate therapy.
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