ampicillin and Amikin pediatric Interactions

Interactions between ampicillin and Amikin pediatric (amikacin)

ampicillin and amikacin (Moderate Drug-Drug)

ADJUST DOSING INTERVAL: Ampicillin may inactivate aminoglycosides in vivo and in vitro. The mechanism is complexation with the aminoglycoside. Typically, this effect is significant only in patients with renal failure or if the agents are mixed in the same IV container or line. Lower serum aminoglycoside levels may be seen, and dosage adjustments may be necessary.

MANAGEMENT: Ampicillin and aminoglycosides should be administered separately during combined therapy.