Drug interactions between ampicillin and Garamycin
| Results for the following 2 drugs: |
|---|
| ampicillin |
| Garamycin (gentamicin) |
Interactions between your selected drugs
ampicillin ↔ gentamicin
Applies to:ampicillin and Garamycin (gentamicin)
ADJUST DOSING INTERVAL: Ampicillin may inactivate aminoglycosides in vivo and in vitro. The mechanism is complexation with the aminoglycoside. Typically, this effect is significant only in patients with renal failure or if the agents are mixed in the same IV container or line. Lower serum aminoglycoside levels may be seen, and dosage adjustments may be necessary.
MANAGEMENT: Ampicillin and aminoglycosides should be administered separately during combined therapy.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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