amphocin and Arduan Interactions

Interactions between amphocin(amphotericin B) and Arduan (pipecuronium)

amphotericin B and pipecuronium (Moderate Drug-Drug)

MONITOR: Amphotericin commonly causes renal potassium and magnesium wasting. As a result, serum potassium is decreased, and the pharmacologic effects of some neuromuscular blocking agents are enhanced.

MANAGEMENT: To decrease or prevent this interaction, magnesium and potassium levels should be monitored, and the patient's body stores of potassium and magnesium should be replenished even before the expected fall in serum potassium occurs.